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ProcessBenefitsWhat is Germ Free?
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THE BENEFITS OF GERM-FREE OVER TRADITIONAL SPF


Conventional and SPF eggs have inherent disadvantages
  • They carry bacterial contamination, outside and inside the shell (2 to 10% of eggs carry internal contamination)
  • Decreased hatchability
  • Potential contamination of Master / Working Viral Seeds
  • Contamination of PCC / CEF vaccine production lots
  • Contamination of other products e.g. antibodies
  • Increased risk of adverse events
  • Interference with adventitious / extraneous agent tests
  • Results in loss of R & D productivity and even loss of vaccine batches
Susceptible to infectious disease / loss of SPF status
  • Results in lack of continuity of supply
Germ-Free eggs from Ovagen provide the solution
  • Completely free of infection
  • Loss of SPF status detected before sending to customer (unlike conventional SPF eggs)
  • Fully compliant with GMP
Comparison of SPF and Ovagen GF Eggs
Criteria SPF GF
Susceptible to internal bacterial contamination Yes
(Typically 10% of eggs)
No
Risk of vaccine batch loss associated with contamination Yes
(Up to 20% of batches)
No
Financial Rationale Poor Compelling
(ROI > 100%)
Bio-Security Low High
Susceptible to disease epidemics (e.g. Avian Influenza) Yes No
Delay in identifying loss of SPF/Regulatory Compliant status Yes No
GMP Compliant No Yes
Suitability for high value, specialist use (Master Viral Seeds, PCC etc) Low High
Ovagen

NEW FACILITIES

Ovagen

New Facilities (2500msq)

  • First generation germ-free flocks
  • Isolators, Incubators
  • Laboratories
  • Pilot scale (25%) commercial production
  • R&D
  • Head Office

Lower Floor Provides:

  • SPF flocks
  • Large Germ-Free (GF) Isolators
  • GF suite for flock of 1000 birds
  • GF 'space' suits & decontamination showers
  • GF feed handling
  • GF egg collection & packaging

Upper Floor Provides:

  • SPF showers
  • Incubating/Hatching Isolators
  • Transport Isolators
  • Laboratories & QA
  • Head Offices
  • Site BMS & IT facilities

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