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Ovagen Group Limited Announce the Launch of the World’s First Germ-Free Egg

  • This innovative and disruptive technology will set a new ‘gold standard in the market’ eliminating bacterial contamination and potential for increased viral yield in egg based vaccine manufacture
  • This ground-breaking development will support the manufacturing of vaccines and scientific research
  • These bacteria, or ‘germfree’, eggs will be available for commercial sale in Q2 this year

25 April 2022, Ballina, Mayo, Ireland: Biotechnology company Ovagen Group Limited has today announced the achievement of the world’s first bacteria free (‘germfree’) eggs. These eggs are from a bacteria free flock of birds, and for use in the production of human and animal vaccine manufacture and in cutting edge scientific research. 

Chicken eggs have been in clinical use for vaccine manufacture and biopharmaceutical research for over 100 years. However, bacterial contamination of eggs has always been a problem for the vaccine industry. This has now been addressed by Ovagen’s multi-skilled research team. 

Ovagen’s superior quality germfree eggs will therefore set a new gold standard in the market. The biology of germfree eggs may also allow much greater viral yield of certain vaccines. These Germ Free eggs will be available for commercial sale in Q2 2022.

Dr. Catherine Caulfield, Ovagen CEO, commented: “The achievement of germfree eggs is the result of over a decade of research & development for Ovagen, and represents a great advancement of our technology. I would like to sincerely thank our committed and dedicated team for their part in developing this world’s first innovative and disruptive technology.” 

Dr. Leonard Moran, Ovagen Chairman and experienced entrepreneur, said: “Vaccine and biopharmaceutical medicine is a key part of human health, as evidenced by the Covid-19 pandemic. I am really pleased that Ovagen will play such an important role in advancing the science in this area.”

European Research funding, through Horizon 2020, and shareholder matched funds have been instrumental in allowing Ovagen take the product from proof of concept to germ free eggs available for customer evaluation. The company is now poised for scale up and commercialisation.

Kevin Burke, National Director for Horizon Europe at Enterprise Ireland said, “This is very positive news for Dr. Caulfield and her team at Ovagen Group. Ovagen Group’s engagement with the European Framework Programmes and the award of competitive funding under the SME Instrument has significantly progressed the company’s research and innovation ambitions to advance commercialisation and its position to scale. 

“The SME Instrument Programme has been succeeded by the European Innovation Council (EIC) Accelerator Programme in Horizon Europe. Enterprise Ireland encourages all innovative Irish start-ups and SMEs to closely look at the opportunities under the EIC and the wider Horizon Europe Programmes to support their innovation and scale-up ambitions.”

About Ovagen Group Limited. Ballina, Mayo, Ireland. 

Ovagen Group Limited is an innovation-based biotechnology company, led by experienced entrepreneurs, providing specialist contract products and services to the biopharmaceutical, pharmaceutical and vaccine industries. The companyhas developed a proprietary process of producing Germ Free chicken eggs and Germ Free birds in commercial quantities for use primarily in the pharmaceutical industry.

For more information, please contact:

Peg Connor (Administrative Office Manager):

Microbiological Assessment and Evaluation of Virus Yield in Germ-free Chicken Eggs

We are delighted to announce the publication of the collaboration between Ovagen Group Limited and The Pirbright Institute on the execution of the first viral yield study using Germ-Free Eggs. The results of the study showed an increased yield of H1N1 when inoculated into Germ-Free eggs compared with eggs from Specific Pathogen Free hens.

Read the full article: https://openmicrobiologyjournal.com/VOLUME/18/ELOCATOR/e18742858343360/

WDC Leads €2m Investement In Biotechnology Company Ovagen

The Western Development Commission has led a €2 million Series A equity investment round in Ovagen Group Limited, a biotechnology company based in Ballina, Co Mayo.

The funding is aimed at accelerating the production of Ovagen’s germ-free eggs.

Read the full article: https://lnkd.in/dxs86DUa

Enterprise Ireland HBAN Boole Investments DeepIE Ventures Spark Crowdfunding

Photo credit: Michael Mc Laughlin

Ovagen Group Limited recently attended the 11th Annual Avian Model Systems Conference at the University of Plymouth, UK (11-14SEP2023).  It was a wonderful four days of fantastic avian research presentations ranging from developmental biology and evolution to immunology, novel techniques, and the application of avian models in biomedical research, diagnostics, and vaccine production. The plenary discussion and the subsequent PI meeting highlighted the strength and breadth of the avian research community, and the desire to forge a closer network with an online platform and regional resource centres.

At the global meeting, Dr. Martin Murphy presented a flash talk entitled: A novel method for the production of the world’s first avian Germ Free Eggs and a poster was prepared for exhibition at the meeting.  There were three poster exhibition sessions at the meeting which was a great opportunity for Ovagen to present and discuss the unique advantages of germ free eggs in eliminating contamination in vaccine manufacture and in increasing the viral yield per egg. The diverse applications of Germ Free eggs for vaccine manufacture, oncology, CDMO’s CRO’s and research applications was highlighted.  Attendance by Ovagen management at future global vaccine conferences and scientific meetings is planned for 2023/2024.

We Are Hiring – Production Technician

Who We Are – Ovagen Group Limited

We are an innovation based biotechnology company that has developed a proprietary process of producing the world’s first Germ Free eggs, for use in vaccine manufacture and other pharmaceutical and research applications.  Germ free eggs are the highest quality products available to produce medicines like vaccines, reducing contamination and the need for antimicrobials, as well as improving sustainability and environmental impacts.

We also specialise in avian transgenic technology and have a fully equipped transgenic laboratory.

As the first company in the world to produce commercial quantities of Germ Free eggs from  our state-of-the-art avian facility, we have recently been awarded €10M funding by the European Commission and plans are in place to build two additional Germ Free production facilities and a logistics building, to scale-up  production to four million Germ Free eggs annually.

At Ovagen, we pride ourselves on scientific excellence, and we are passionate about the impact of our disruptive technology in transforming the way vaccines are produced to give security of supply and improve global immunisation coverage.

About the position

Our commercialisation plans are now being accelerated. Additionally, a series of studies over the next year are likely to show additional key advantages of Germ Free eggs, further increasing product demand.

This position of Technician is a key appointment and the successful candidate will report directly to the Senior Project Director in our HQ in Ballina, County Mayo.

Key responsibilities include;

  • Support the Senior Project Director, to ensure the company has Germ Free (GF) eggs available for evaluation and validation by customers and in scale-up of production.
  • Responsible for planning and co-ordination of all procedures including day to day care and maintenance to the highest standards of welfare.
  • Day to day procedures involving germ free isolators including but not limited to: set up; aseptic transfer of sterile items and environmental sampling for microbiological analysis.
  • Responsible for biosecurity and environmental monitoring in compliance with SOPs and Pharmacopeial requirements.
  • Responsible for the preparation, revision of and compliance with SOPs and meticulous record keeping to GMP standards.
  • Support the Senior Project Director with the operation and maintenance of the Building Management System (BMS).

The successful candidate will have;

  • A degree in Bioveterinary Science/Veterinary Nursing/relevant Science degree
  • 2+ years’ practical experience of working in a research environment preferably with aseptic techniques.
  • Strong oral and written communication skills
  • Team Player who can collaboratively work with cross-functional groups
  • High energy and resilience level, team building skills and an ability to anticipate and address potential technical issues
  • Strong IT skills i.e. very familiar with Microsoft Word, Microsoft Excel and Microsoft PowerPoint

What we Offer

This is a very important role in Ovagen, and as such, the successful candidate will enjoy a salary befitting this. 

This is an opportunity to join Ovagen Group at an exciting time when we are poised for dynamic growth.

If you are interested in applying to the role, please send your CV and covering letter to [email protected]

HBAN leads €1.1M investment in Mayo biotech company, Ovagen Group Ltd

  • Ovagen has produced the world’s first ‘germ-free’ eggs, a groundbreaking development for vaccine production
  • Ovagen expects that the significant potential of its technology will see it reach €42M in revenues by year-end 2027
  • Funding will be used to carry out R&D evaluation trials on vaccine batches; officially launch the world’s first germ-free eggs targeting major world drug manufacturers; and for the appointment of key additional personnel
  • Company will expand its team by 65 in the next five years

Ballina, Mayo, 3rd February, 2023HBAN (Halo Business Angel Network), the all-island organisation responsible for the promotion of business angel investment, and a joint initiative of Enterprise Ireland and InterTradeIreland, today announces that its syndicates, Irrus Investments and WxNW, have led a €1.1M oversubscribed funding round in Ovagen, the world’s first producer of germ-free eggs. Funding also came from the Western Development Commission (WDC) and an existing shareholder.

Ovagen’s groundbreaking proprietary process is a world-first and addresses a problem that sees up to 20% of egg-based vaccine batches being destroyed. Due to the significance of its product, Ovagen expects to add 65 jobs over the next five years, with revenues reaching €42M by year-end 2027.

Every year, in excess of one billion eggs are used globally as ‘bio-reactors’ to support the development of life-saving human and animal health vaccines. Viruses are injected into the eggs to propagate the virus, which vaccine manufacturers can then use to develop vaccines for diseases including the flu, yellow fever, mumps and measles. However, currently, one-in-five eggs become contaminated, leaving the vaccines they create unfit for use. It is a multi-million-euro problem for the world’s vaccine manufacturing industry.

Following seven years of research and development, Ovagen has now addressed this issue with its superior quality-verified ‘germ-free’ eggs, produced in the company’s Ballina, Co. Mayo, headquarters. The process and technology – which is protected by patents and trade secrets – ensures no bacteria can enter an egg through its porous shell after it is laid.

The latest funding brings the total amount received by Ovagen to-date to more than €19M. It will be used to carry out R&D evaluation trials on vaccine batches, to officially launch the world’s first germ-free eggs, targeting major world drug manufacturers and the appointment of key additional personnel. The company will also seek to prove that its germ-free eggs give a higher viral yield, which the founders believe can significantly reduce the large number of eggs required to produce vaccines – and with it, the costs and logistical issues of transporting those eggs.

Ovagen expects that from its site in Ballina, it will be producing four million eggs annually by 2027, with revenues reaching €42M by the end of that year. This will be supported by increasing the team to 77, up from 12, over the next five years. The company also has plans to build three additional facilities in Ballina, as well as establishing global satellite facilities close to drug manufacturing sites.

Dr. Catherine Caulfield, co-founder and CEO, Ovagen, said:Currently, vaccines are developed using Specific Pathogen Free (SPF) eggs. While these are free of many bacteria and viruses, they are not germ-free and a significant proportion become contaminated with bacteria.

“Our funders have been instrumental in supporting us on our long journey to make a concept a reality. At critical stages in our development, our angel investors have not only provided us with their financial backing, but they have also introduced us to other potential investors, as well as their highly influential industry contacts. Their support, along with the tireless dedication of the Ovagen team, puts us in a very strong position as we prepare to go to market with the world’s first germ-free egg.”

Declan MacFadden, spokesperson for HBAN’s WxNW syndicate, said:The Ovagen team has shown incredible perseverance in pursuit of an idea that many deemed was impossible. The global potential of the company’s technology is vast and that is why this is the second time HBAN syndicates have backed Ovagen. Our investors were also impressed by the unwavering ambition and track record of the founders, who previously sold a company for €25M, giving some early investors a 68X return on their investments.

“Angel investment is a key enabler for early-stage businesses as it helps them to leverage additional funding, while also providing them with access to industry experts who can provide strategic support and introductions to their network of contacts. Ovagen is now in prime position to launch its product and we are excited to see the impact that this groundbreaking development has in a highly lucrative global market.”

Allan Mulrooney, Interim CEO of Western Development Commission, said: The WDC is a long-term investor of Ovagen. The company has continued to grow and innovate to create a world class, economically sustainable product. This round of Investment supported by WDC will enable Ovagen to expand their market and create up to 77 high level roles from its base in Ballina, Mayo. This investment underlines the importance of supporting innovation driven enterprises, leading the success of the existing biotechnology ecosystem in Ireland’s western region. This is a great example of a local company operating on a global scale.”

– Ends –

About Ovagen Group Ltd.

Ovagen Group Limited is an innovation-based biotechnology company, led by experienced entrepreneurs, providing specialist products to the biopharmaceutical, pharmaceutical and vaccine industries. The company has developed a proprietary process of producing Germ Free chicken eggs in commercial quantities for use primarily in the pharmaceutical and Biopharmaceutical industry.

For more information, please contact:

Peg Connor (Administrative Office Manager):

About HBAN

HBAN is a joint initiative of Enterprise Ireland and InterTradeIreland, dedicated to the all-island promotion of business angel investment. The HBAN umbrella group supports the early-stage entrepreneurial community across the island of Ireland and actively works to increase the number of angel investors investing in early-stage companies.  The all-island umbrella group works on a regional basis to support the formation of new angel networks and works with existing angel networks to develop their capability and capacity, and across a range of industry sectors. HBAN also acts as a voice to Government, stakeholders, business and the media to promote the interests and needs of the wider angel investment community. HBAN is managed by Furthr in partnership with the regional Irish BICs in Cork, Galway & Waterford and with Clarendon Fund Managers in Northern Ireland. Further information is available at www.hban.org

About Enterprise Ireland

Enterprise Ireland is the Irish government organisation responsible for the development and growth of Irish enterprises in world markets. The organisation works in partnership with Irish enterprises to help them start, grow, innovate and win export sales in global markets. In this way, Enterprise Ireland supports sustainable economic growth and regional development, and help create and sustain employment in Ireland. www.enterprise-ireland.com

About InterTradeIreland

InterTradeIreland is the only organisation which has been given responsibility by both governments to boost North South economic co-operation to the mutual benefit of Northern Ireland and Ireland. InterTradeIreland is a powerful resource for business growth, helping SMEs through a strong mix of funding, innovation supports and meaningful contacts. www.intertradeireland.com

Media Contact:

Helen Morrogh

Comit Communications

[email protected]

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